Biological functions and therapeutic potential of acylation by histone acetyltransferases

Histone lysine acylation is a major class of histone post-translational modifications involved in essential biological activities, such as transcriptional regulation, DNA-damage repair, and cell-cycle progression. Abnormal strongly associated with various diseases, cancer. Thus, acetyltransferases (HATs), the “writers” that catalyze acylation, are promising targets for cancer treatment. Rapid developments structural biology artificial intelligence have facilitated development drugs targeting HATs. To provide new ideas exploring novel HAT modifiers high efficiency selectivity, this article reviews relationships between illustrates catalytic mechanisms through biology, summarizes research progress modifiers.